Sampling strategy effects on in vivo 2D J-Resolved spectroscopy quantification
نویسندگان
چکیده
Introduction Two-dimensional (2D) spectroscopy has great potential to unambiguously distinguish metabolites [1,2]. J-Resolved magnetic resonance spectroscopy allows the indirect dimension to be encoded following a various number of echo times. Till now, in vivo 2D MRS related studies did not investigate sampling strategies of the indirect dimension as a way of improving the quantification of metabolite concentrations. This paper presents a statistical study carried out on simulated J-PRESS data containing macromolecular contamination. 2D J-Resolved spectroscopy quantification accuracy was evaluated for several sampling strategies and compared to the one obtained in 1D MRS designed with the same acquisition time. In vivo 2D quantification following these strategies is shown.
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